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Matthew

Lane

Matthew Lane is a Graduate Research Assistant in the Computational and Predictive Biology Group at Oak Ridge National Laboratory working under Dr. Dan Jacobson.His current research centers around the application of statistical, graph theoretical, machine and deep learning methods for prediction and analysis of complex biological systems using the leadership class systems Andes, Summit, and Perlmutter.Research undertakings currently include:- Using Explainable AI to create massive Predictive Expression Networks for use in Multiplex Omics models.- Employing geometric deep learning for node embedding and link prediction on large and sparse networks.- Metabolomic profile network creation through peak extraction and statistical processing of LC/GC-MS data.- Scientific Software engineering for the production of well-tested and documented packages for publication.- Topological Perturbation of networks for the phenotypic prediction of genetic modulation.Matthew Lane earned his M.S. in Computer Science under Dr. Sharlee Climer at the University of Missouri in St. Louis, working on network theory techniques for the analysis of cerebrospinal fluid metabolites in patients of Alzheimer’s disease. After his tenure at the University of Missouri, he worked as a software engineer at Bayer Crop Science, developing software for the collection, storage, and analysis of crops in the field.He actively volunteers to teach coding and robotics to local high school students and community members working with the East Tennessee STEM Hub.

Session Chair

This person is not chairing any sessions.

Presenter

Minisymposium Presentation
Monday, June 16, 2025
12:50
-
13:20
CEST
AI-Driven Systems Biology for Addiction: Large-Scale Multi-Omics Network Modeling and AI Agents for Mechanistic Discovery

Author

Minisymposium Presentation
Monday, June 16, 2025
12:50
-
13:20
CEST
AI-Driven Systems Biology for Addiction: Large-Scale Multi-Omics Network Modeling and AI Agents for Mechanistic Discovery

Poster

P30 - The MENTOR Interpretation Agent: From Network Embeddings to Mechanistic Narratives via Retrieval-Augmented LLMs

Tuesday, June 27, 2023 19:30
Climate, Weather and Earth Sciences
Chemistry and Materials
Computer Science, Machine Learning, and Applied Mathematics
Applied Social Sciences and Humanities
Engineering
Life Sciences
Physics
With
Anna H.C. Vlot (Oak Ridge National Laboratory); Matthew Lane (Oak Ridge National Laboratory; Bredesen Center for Interdisciplinary Graduate Research and Education, University of Tennessee-Knoxville); Kyle A. Sullivan (Oak Ridge National Laboratory); Peter Kruse (Oak Ridge National Laboratory; Bredesen Center for Interdisciplinary Graduate Research and Education, University of Tennessee-Knoxville); John Dandy and Selin Kaplanoglu (Oak Ridge National Laboratory); Alice Townsend and Jean Merlet (Oak Ridge National Laboratory; Bredesen Center for Interdisciplinary Graduate Research and Education, University of Tennessee-Knoxville); and Daniel A. Jacobson (Oak Ridge National Laboratory)

P32 - Multi-Omic Single Cell Network Perturbation for Phenotypic Prediction

Tuesday, June 27, 2023 19:30
Climate, Weather and Earth Sciences
Chemistry and Materials
Computer Science, Machine Learning, and Applied Mathematics
Applied Social Sciences and Humanities
Engineering
Life Sciences
Physics
With
Matthew Lane (Oak Ridge National Laboratory, University of Tennessee); Erica Prates (Oak Ridge National Laboratory); Alice Townsend and Jean Merlet (Oak Ridge National Laboratory, University of Tennessee); Christiane Alvarez and Alana Wells (Oak Ridge National Laboratory); and Daniel Jacobson (Oak Ridge National Laboratory, University of Tennessee)